Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …

Context: A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been
reported. This is the first study that uses liquid chromatography–tandem mass spectrometry …

Adrenal C19 steroids, dehydroepiandrostenedione (DHEA (S)) and androstenedione (A4),
play a critical role in castration resistant prostate cancer (CRPC) as they are metabolised to …

Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is
implicated in the development and progression of castration resistant prostate cancer …

For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-
dihydrotestosterone are the only potent androgens in the context of human physiology. The …

Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …

The pathways of androgen biosynthesis in human beings have been studied for decades,
and the major pathways and enzymes responsible for testosterone and dihydrotestosterone …

Dihydrochalcones are a class of secondary metabolites, for which demand in biological and
pharmacological applications is still growing. They posses several health-endorsing …

Risk factors of type 2 diabetes mellitus (T2D) and cardiovascular disease (CVD) cluster
together and are termed the metabolic syndrome. Key factors driving the metabolic …