Abstract Alkaline phosphatase (ALP; EC 3. I. 3.1.) is an ubiquitous membrane-bound
glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values …

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …

Hypophosphatasia (HPP) results from ALPL mutations leading to deficient activity of the
tissue-non-specific alkaline phosphatase isozyme (TNAP) and thereby extracellular …

Our knowledge of the structure and function of alkaline phosphatases has increased greatly
in recent years. The crystal structure of the human placental isozyme has enabled us to …

Bone cells compose a population of cells of heterogeneous origin but restricted function with
respect to matrix formation, mineralization, and resorption. The local, mesenchymal origin of …

A review of the human alkaline phosphatases dealing specifically with (1) the gene loci,(2)
characterization and discrimination of the various enzymes,(3) polymorphism at the enzyme …

Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor
outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising …

A review and discussion of new knowledge on the structure and function of mammalian
alkaline phosphatases (APs) gained over the last 25 years. It covers:* The structure …

In man, there are multiple forms of alkaline phosphatase encoded by at least three
homologous genes: placental, intestinal, and liver/bone/kidney. This report describes the …

Hypophosphatasia is an inherited disorder characterized by defective bone mineralization
and a deficiency of serum and tissue liver/bone/kidney alkaline phosphatase (L/B/K ALP) …