Our understanding of G protein-coupled receptor (GPCR) activation has evolved during the
last ten years, both at a molecular level thanks to the resolution of several crystal structures …

Allosteric receptor modulation is an attractive concept in drug targeting because it offers
important potential advantages over conventional orthosteric agonism or antagonism …

Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that
maintains extracellular Ca2+ homeostasis through the regulation of parathyroid hormone …

The calcium sensing receptor (CaSR) is a class C G-protein-coupled receptor that is crucial
for the feedback regulation of extracellular free ionised calcium homeostasis. While …

Metabotropic GABA B receptor is a G protein-coupled receptor (GPCR) that mediates slow
and prolonged inhibitory neurotransmission in the brain. It functions as a constitutive …

Ca2+ homeostasis in serum. Here, we present the cryo-electron microscopy structures of the
CaSR in the inactive and agonist+ PAM bound states. Complemented with previously …

The calcium-sensing receptor (CASR) is expressed in parathyroid hormone (PTH)-secreting
cells of the parathyroid gland and cells lining the renal tubule. The activated CASR …

Family C of human G‐protein‐coupled receptors (GPCRs) is constituted by eight
metabotropic glutamate receptors, two γ‐aminobutyric acid type B (GABAB1–2) subunits …

Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing
intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea …

Three types of morphologically and functionally distinct taste cells operate in the mammalian
taste bud. We demonstrate here the expression of two G-protein-coupled receptors from the …