Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Next‐generation vaccines: nanoparticle‐mediated DNA and mRNA delivery

W Ho, M Gao, F Li, Z Li, XQ Zhang… - Advanced healthcare …, 2021 - Wiley Online Library
Nucleic acid vaccines are a method of immunization aiming to elicit immune responses akin
to live attenuated vaccines. In this method, DNA or messenger RNA (mRNA) sequences are …

Poly(l‐Histidine)‐Mediated On‐Demand Therapeutic Delivery of Roughened Ceria Nanocages for Treatment of Chemical Eye Injury

CJ Yang, DD Nguyen, JY Lai - Advanced Science, 2023 - Wiley Online Library
Abstract Development of topical bioactive formulations capable of overcoming the low
bioavailability of conventional eye drops is critically important for efficient management of …

[HTML][HTML] Engineering nanoparticle toolkits for mRNA delivery

B Sun, W Wu, EA Narasipura, Y Ma, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Dendritic mesoporous nanoparticles: structure, synthesis and properties

C Xu, C Lei, Y Wang, C Yu - Angewandte Chemie International …, 2022 - Wiley Online Library
Recently, dendritic mesoporous silica nanoparticles with widespread applications have
attracted great interest. Despite many publications (> 800), the terminology “dendritic” is …

Defect‐rich adhesive nanozymes as efficient antibiotics for enhanced bacterial inhibition

F Cao, L Zhang, H Wang, Y You… - Angewandte Chemie …, 2019 - Wiley Online Library
Nanozymes have emerged as a new generation of antibiotics with exciting broad‐spectrum
antimicrobial properties and negligible biotoxicities. However, their antibacterial efficacies …

Versatile types of organic/inorganic nanohybrids: from strategic design to biomedical applications

N Zhao, L Yan, X Zhao, X Chen, A Li, D Zheng… - Chemical …, 2018 - ACS Publications
Organic/inorganic nanohybrids have attracted widespread interests due to their favorable
properties and promising applications in biomedical areas. Great efforts have been made to …

Silica-based nanoparticles for biomedical applications: from nanocarriers to biomodulators

Y Yang, M Zhang, H Song, C Yu - Accounts of chemical research, 2020 - ACS Publications
Conspectus Silica-based nanoparticles (SNPs) are a classic type of material employed in
biomedical applications because of their excellent biocompatibility and tailorable …

The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

Bioinspired nanotopographical design of drug delivery systems

JA Finbloom, C Huynh, X Huang… - Nature Reviews …, 2023 - nature.com
Effective drug delivery is important in the treatment of various biomedical conditions, ranging
from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can …