Potential mechanisms of bisphenol A (BPA) contributing to human disease

I Cimmino, F Fiory, G Perruolo, C Miele… - International journal of …, 2020 - mdpi.com
Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce
polycarbonate plastic, widely used in the packaging for food and drinks, medical devices …

G protein–coupled estrogen receptor GPER: molecular pharmacology and therapeutic applications

JB Arterburn, ER Prossnitz - Annual review of pharmacology …, 2023 - annualreviews.org
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

An overview on estrogen receptors signaling and its ligands in breast cancer

MZI Khan, M Uzair, A Nazli, JZ Chen - European Journal of Medicinal …, 2022 - Elsevier
Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

Estrogen biology: new insights into GPER function and clinical opportunities

ER Prossnitz, M Barton - Molecular and cellular endocrinology, 2014 - Elsevier
Estrogens play an important role in the regulation of normal physiology, aging and many
disease states. Although the nuclear estrogen receptors have classically been described to …

Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives

M Barton, EJ Filardo, SJ Lolait, P Thomas… - The Journal of steroid …, 2018 - Elsevier
Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo?

J Luo, D Liu - Frontiers in endocrinology, 2020 - frontiersin.org
Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—
mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses …

Estrogen signaling through the transmembrane G protein–coupled receptor GPR30

ER Prossnitz, JB Arterburn, HO Smith… - Annu. Rev …, 2008 - annualreviews.org
Steroids play an important role in the regulation of normal physiology and the treatment of
disease. Steroid receptors have classically been described as ligand-activated transcription …

[HTML][HTML] Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues

GGJ Hazell, ST Yao, JA Roper… - The Journal of …, 2009 - ncbi.nlm.nih.gov
Recently, the G protein-coupled receptor GPR30 has been identified as a novel oestrogen
receptor (ER). The distribution of the receptor has been thus far mapped only in the rat …

International union of basic and clinical pharmacology. XCVII. G protein–coupled estrogen receptor and its pharmacologic modulators

ER Prossnitz, JB Arterburn - Pharmacological reviews, 2015 - ASPET
Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

A plurality of molecular targets: The receptor ecosystem for bisphenol-A (BPA)

H MacKay, A Abizaid - Hormones and behavior, 2018 - Elsevier
Bisphenol-A (BPA) is a well-known endocrine disrupting compound (EDC), capable of
affecting the normal function and development of the reproductive system, brain, adipose …