Tardive dyskinesia has been and continues to be a significant problem associated with long-
term antipsychotic use, but its pathophysiology remains unclear. In the last 10 years …

Bradykinesia is a prominent phenotype of Parkinson's disease, depression, and other
neurological conditions. Disruption of dopamine (DA) transmission plays an important role …

Regulator of G-protein signaling 9-2 (RGS9-2), a member of the RGS family of Gα GTPase
accelerating proteins, is expressed specifically in the striatum, which participates in …

Recent data from positron emission tomography (PET) imaging studies suggest the
possibility of studying synaptic transmission in vivo in humans. The approach will require a …

Dopamine-mediated behaviors and certain biochemical and molecular events associated
with these behaviors were examined following continuous infusion of the D 1 dopamine …

The D3 dopamine (DA) receptor is a member of the D2-like DA receptor family. While the D2
receptor is abundant especially in motor-regions of the striatum, the D3 receptor shows a …

The release of [3H] GABA from slices of rat substantia nigra pars reticulata induced by
increasing extracellular K+ from 6 to 15mM in the presence of 10μM sulpiride was inhibited …

Evidence indicates that mitogen-activated protein kinase (MAPK) pathways play a crucial
role in the neurobiology of the nervous system. In the present study, dopamine receptor …

Dopamine (DA) neurons of the ventral tegmental area (VTA) continue to gain attention as far
more heterogeneous than previously realized. Within the medial aspect of the VTA, the …

The vesicular monoamine transporter 2 (VMAT2) plays a pivotal role in regulating the size of
vesicular and cytosolic dopamine (DA) storage pools within the CNS, and can thus influence …