Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity
LES Netto, LESF Machado - The FEBS Journal, 2022 - Wiley Online Library
Protein phosphorylation is a major post‐translational modification involved in cell signalling
that regulates many physiological and pathological processes. Despite their biological …
that regulates many physiological and pathological processes. Despite their biological …
[HTML][HTML] DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases
Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases
(PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and …
(PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and …
[HTML][HTML] In Vitro and In Silico Investigation of BCI Anticancer Properties and Its Potential for Chemotherapy-Combined Treatments
Simple Summary BCI is an allosteric inhibitor of DUSP6 phosphatase, which is a negative
regulator of MAPK kinases involved in numerous cellular processes such as proliferation …
regulator of MAPK kinases involved in numerous cellular processes such as proliferation …
[HTML][HTML] The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer's disease
X Zhao, L Xiong, L She, L Li, P Huang… - Biomedicine & …, 2022 - Elsevier
Protein tyrosine phosphatases (PTPs) are important regulator of neuronal signal
transduction and a growing number of PTPs have been implicated in Alzheimer's disease …
transduction and a growing number of PTPs have been implicated in Alzheimer's disease …
To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling
Accumulating evidence has reached the consensus that the balance of phosphorylation
state of signaling molecules is a pivotal point in the regulation of cell signaling. Therefore …
state of signaling molecules is a pivotal point in the regulation of cell signaling. Therefore …
[HTML][HTML] Dual-specificity phosphatase 4 regulates STAT5 protein stability and helper T cell polarization
WY Hsiao, YC Lin, FH Liao, YC Chan, CY Huang - PloS one, 2015 - journals.plos.org
Immune responses are critically regulated by the functions of CD4 helper T cells. Based on
their secreted cytokines, helper T cells are further categorized into different subsets like Treg …
their secreted cytokines, helper T cells are further categorized into different subsets like Treg …
[HTML][HTML] Identification of a potent cytotoxic pyrazole with anti-breast cancer activity that alters multiple pathways
In this study, we identified a novel pyrazole-based derivative (P3C) that displayed potent
cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50 …
cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50 …
Crystal structure of monkeypox H1 phosphatase, an antiviral drug target
W Cui, H Huang, Y Duan, Z Luo, H Wang… - Protein & …, 2023 - academic.oup.com
Since its appearance in May 2022, monkeypox has spread to> 100 countries and afflicted
tens of thousands of people. Individuals infected with monkeypox present a fever, an …
tens of thousands of people. Individuals infected with monkeypox present a fever, an …
[HTML][HTML] Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates
Inositol pyrophosphates (PP-InsPs) are" energetic" intracellular signals that are ubiquitous in
animals, plants, and fungi; structural and biochemical characterization of PP-InsP metabolic …
animals, plants, and fungi; structural and biochemical characterization of PP-InsP metabolic …
[HTML][HTML] Critical roles of dual-specificity phosphatases in neuronal proteostasis and neurological diseases
N Bhore, BJ Wang, YW Chen, YF Liao - International journal of molecular …, 2017 - mdpi.com
Protein homeostasis or proteostasis is a fundamental cellular property that encompasses the
dynamic balancing of processes in the proteostasis network (PN). Such processes include …
dynamic balancing of processes in the proteostasis network (PN). Such processes include …