Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …

Granulocyte-macrophage colony-stimulating factor (GM-CSF, also called CSF-2) is best
known for its critical role in immune modulation and hematopoiesis. A large body of …

Initiation of pancreatic ductal adenocarcinoma (PDA) is definitively linked to activating
mutations in the KRAS oncogene. However, PDA mouse models show that mutant Kras …

Human plasmacytoid dendritic cells (pDCs) are interleukin-3 (IL-3)-dependent cells
implicated in autoimmunity, but the role of IL-3 in pDC biology is poorly understood. We …

Plant-derived phenylpropanoids (PPPs) compose the largest group of secondary
metabolites produced by higher plants, mainly, for the protection against biotic or abiotic …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is frequently
mutated or overexpressed in a large number of tumors such as carcinomas or glioblastoma …

The limited efficacy of currently approved immunotherapies in EGFR-driven lung
adenocarcinoma (LUAD) underscores the need to better understand alternative …

The hair follicle stem cell niche is an immune-privileged microenvironment, characterized by
reduced antigen presentation, thus shielding against permanent immune-mediated tissue …

Aims: To evaluate mechanisms underlying modulation of inflammatory chemokines in
primary human keratinocytes (normal human epidermal keratinocytes) and repair-related …

Background Indigo naturalis and its refined formulation, Lindioil, are effective in treating
psoriatic symptoms topically. Indirubin is the active ingredient in indigo naturalis. Objectives …