Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

Introduction Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are
anticipated to be a useful tool for conducting proarrhythmia risk assessments of drug …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) have been widely
proposed as in vitro models of myocardial physiology and disease. A significant obstacle …

Cardiac electrophysiology models have been developed for over 50 years, and now include
detailed descriptions of individual ion currents and sub-cellular calcium handling. It is …

An in vitro drug-induced cardiotoxicity assay is a critical step in drug discovery for clinical
use. The use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) …

Background: Cardiac repolarization abnormalities in drug-induced and genetic long-QT
syndrome may lead to afterdepolarizations and life-threatening ventricular arrhythmias …

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a
new model for safety pharmacology. So far, a thorough description of their basic …

Rationale: Drug-induced proarrhythmia is so tightly associated with prolongation of the QT
interval that QT prolongation is an accepted surrogate marker for arrhythmia. But QT interval …