Integrating plant molecular farming and materials research for next-generation vaccines
YH Chung, D Church, EC Koellhoffer, E Osota… - Nature Reviews …, 2022 - nature.com
Biologics—medications derived from a biological source—are increasingly used as
pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial …
pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial …
Carrot cells: a pioneering platform for biopharmaceuticals production
S Rosales-Mendoza, MA Tello-Olea - Molecular biotechnology, 2015 - Springer
Carrot (Daucus carota L.) is of importance in the molecular farming field as it constitutes the
first plant species approved to produce biopharmaceuticals for human use. In this review …
first plant species approved to produce biopharmaceuticals for human use. In this review …
Recent advances and safety issues of transgenic plant-derived vaccines
Z Guan, B Guo, Y Huo, Z Guan, J Dai, Y Wei - Applied microbiology and …, 2013 - Springer
Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant
genetic engineering technology with an organism's immunological response. This …
genetic engineering technology with an organism's immunological response. This …
High-level expression of human interferon alpha-2b in transgenic carrot (Daucus carota L.) plants
Y Luchakivskaya, O Kishchenko, I Gerasymenko… - Plant cell reports, 2011 - Springer
In this study, we report the obtaining of carrot plants expressing human interferon alpha-2b
via Agrobacterium-mediated transformation using two vector constructs containing the …
via Agrobacterium-mediated transformation using two vector constructs containing the …
Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge
S Rosales-Mendoza, RE Soria-Guerra… - Plant cell reports, 2008 - Springer
Diarrheal diseases caused by Vibrio cholerae and enterotoxigenic Escherichia coli (ETEC)
are worldwide health problems that might be prevented with vaccines based on edible …
are worldwide health problems that might be prevented with vaccines based on edible …
Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional …
S Rosales‐Mendoza, ÁG Alpuche‐Solís… - The Plant …, 2009 - Wiley Online Library
Enterotoxigenic Escherichia coli (ETEC) strains are important pathogens in developing
countries. Some vaccine formulations containing the heat labile toxin B subunit (LTB) have …
countries. Some vaccine formulations containing the heat labile toxin B subunit (LTB) have …
[PDF][PDF] Genetic transformation of carrot (Daucus carota) and other Apiaceae species
R Baranski - Transgenic Plant J, 2008 - researchgate.net
Carrot (Daucus carota L.) is well known as a model species for plant tissue culture systems.
It is also amenable to genetic modifications using both vector and non-vector methods …
It is also amenable to genetic modifications using both vector and non-vector methods …
Establishment of the Daucus carota SMC-1 cell suspension line for poliovirus vaccine development
M Morales-Aguilar, OC Bolaños-Martínez… - Planta …, 2024 - thieme-connect.com
The development of virus-free, oral vaccines against poliovirus capable of inducing mucosal
protective immunity is needed to safely combat this pathogen. In the present study, a carrot …
protective immunity is needed to safely combat this pathogen. In the present study, a carrot …
Towards the development of an oral vaccine against porcine cysticercosis: expression of the protective HP6/TSOL18 antigen in transgenic carrots cells
E Monreal-Escalante, DO Govea-Alonso, M Hernández… - Planta, 2016 - Springer
Abstract Main conclusion The Taenia solium HP6/TSOL18 antigen was produced in carrot
cells, yielding an immunogenic protein that induced significant protection in an experimental …
cells, yielding an immunogenic protein that induced significant protection in an experimental …
Expression of rabies virus G protein in carrots (Daucus carota)
E Rojas-Anaya, E Loza-Rubio, MT Olivera-Flores… - Transgenic …, 2009 - Springer
Antigens derived from various pathogens can readily be synthesized at high levels in plants
in their authentic forms. Such antigens administered orally can induce an immune response …
in their authentic forms. Such antigens administered orally can induce an immune response …