Modulators of the Hop-HSP90 Protein–Protein Interaction Disrupt KSHV Lytic Replication

MO Okpara, MC Vaaltyn, JL Watson… - ACS Infectious …, 2024 - ACS Publications
The central role of the chaperome in maintaining cellular proteostasis has seen numerous
viral families evolve to parasitically exploit host chaperones in their life cycle. The HSP90 …

[HTML][HTML] Global, regional, and national burden of early-onset gastric cancer

N Tan, H Wu, M Cao, F Yang, X Yan… - Cancer Biology & …, 2024 - pmc.ncbi.nlm.nih.gov
Objective: The burden of gastric cancer (GC) across different age groups needs updating.
We determined the GC global, regional, and national burden profiles and changes in …

Cancer and HIV: The Molecular Mechanisms of the Deadly Duo

A Omar, N Marques, N Crawford - Cancers, 2024 - mdpi.com
Simple Summary Following infection with HIV, individuals are immunocompromised. Their
weakened immune system puts them at a higher risk of certain cancers like Kaposi sarcoma …

Rapid, equipment-free extraction of DNA from skin biopsies for point-of-care diagnostics

JC Manning, JM Boza, E Cesarman, D Erickson - Scientific Reports, 2024 - nature.com
Kaposi's sarcoma (KS) is a cancer affecting skin and internal organs for which the Kaposi's
sarcoma associated herpesvirus (KSHV) is a necessary cause. Previous work has pursued …

[HTML][HTML] The 'Oma's of the Gammas—Cancerogenesis by γ-Herpesviruses

A Banerjee, D Dass, S Mukherjee, M Kaul… - Viruses, 2024 - mdpi.com
Epstein–Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), which are
the only members of the gamma (γ) herpesviruses, are oncogenic viruses that significantly …

Global trends in Kaposi sarcoma incidence and mortality: the need for action to reduce inequalities

C Carrilho, N Lunet - The Lancet Global Health, 2023 - thelancet.com
Kaposi sarcoma is a malignant vascular neoplasia that develops into skin lesions, it can
involve one or multiple internal organs, and it is classified as an AIDS-defining cancer. Four …

Wilms' tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP

AE Morales, R Gumenick, CM Genovese… - Plos …, 2024 - journals.plos.org
In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by KS
herpesvirus (KSHV/HHV-8), remains one of the most common malignancies worldwide …

[PDF][PDF] Pathology of HIV/AIDS

EC Klatt - The Mercer University of Medicine Savannah, 2017 - webpath.med.utah.edu
The human immunodeficiency virus (HIV) was unknown until the early 1980's when
increasing numbers of cases of unusual opportunistic infections and Kaposi sarcoma in …

Modulators of the Hop-HSP90 Protein-Protein Interaction Disrupt Early-Stage of KSHV Lytic Replication

C Veale, M Okpara, M Vaaltyn, A Mahama, F Albericio… - 2024 - chemrxiv.org
The central role of the chaperome in maintaining cellular proteostasis has seen numerous
viral families evolve to parasitically exploit host chaperones in their life cycle. The HSP90 …

A role of BPTF in viral oncogenicity delineated through studies of heritable Kaposi sarcoma

Y Yogev, M Schaffer, M Shlapobersky… - Journal of Medical …, 2024 - Wiley Online Library
Kaposi sarcoma (KS), caused by Herpesvirus‐8 (HHV‐8; KSHV), shows sporadic, endemic,
and epidemic forms. While familial clustering of KS was previously recorded, the molecular …