Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …

Problem The dysregulation of trophoblast functions is one of the leading causes of recurrent
miscarriage (RM), which frustrates 1%‐5% of couples of childbearing ages. Sprouty 4 …

Molecularly targeted therapeutics have revolutionized the treatment of BRAFV600E‐driven
malignant melanoma, but the rapid development of resistance to BRAF kinase inhibitors …

Background Melanoma is among the most malignant immunologic tumor types and is
associated with high mortality. However, a considerable number of melanoma patients …

Background KIT is frequently mutated in gastrointestinal stromal tumors (GISTs), and the
treatment of GISTs largely relies on targeting KIT currently. In this study, we aimed to …

BRAF inhibitor (BRAFi) resistance compromises long-term survivorship of patients with
malignant melanoma, and mutant NRAS is a major mediator of BRAFi resistance. In this …

The identification of liquid biomarkers remains a major challenge to improve the diagnosis of
melanoma patients with brain metastases. Circulating miRNAs packaged into tumor …

Motivation: Cancer is the process of accumulating genetic alterations that confer selective
advantages to tumor cells. The order in which aberrations occur is not arbitrary, and inferring …

BRAF-inhibitor (BRAFi)-resistance compromises long term survivorship of malignant
melanoma patients, and mutant NRAS is a major mediator of BRAFi-resistance. Here …