A wide variety of stationary phases is available for use in preparative chromatography of
proteins, covering different base matrices, pore structures and modes of chromatography …

The paper gives a summary of successful methods for measuring protein mass transfer
kinetics in ion exchange matrices along with models needed to interpret experimental …

The development of purification processes for protein biopharmaceuticals is challenging
due to compressed development timelines, long experimental times, and the need to survey …

Protein dynamic binding capacities on ion exchange resins are typically expected to
decrease with increasing conductivity and decreasing protein charge. There are, however …

Protein transport behavior was compared for the traditional SP Sepharose Fast Flow and the
dextran-modified SP Sepharose XL and Capto S resins. Examination of the dynamic binding …

An experimental study on the interplay of sorbent structure and fluid phase conditions (pH)
has been carried out examining adsorption and transport of bovine serum albumin (BSA) …

Abstract Effects of pH and conductivity on the ion exchange chromatographic purification of
an antigen‐binding antibody fragment (Fab) of pI 8.0 were investigated. Normal sulfopropyl …

Fluorescence scanning confocal microscopy was used in parallel with batch uptake and
breakthrough measurements of transport rates to study the effect of ionic strength on the …

Electrokinetic transport of fluorescent tracer molecules in a bed of porous glass beads was
investigated by confocal laser scanning microscopy. Refractive index matching between …

Custom-synthesized variants of the commercial Capto S resin were used to examine the
effects of resin charge density and dextran content on protein adsorption and intraparticle …