Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration
DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …
Mesenchymal stem cell-derived exosomes for clinical use
M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …
due to their strong immunosuppressive and regenerative effects. One of the key …
Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome
CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …
Exosomes: biogenesis, biologic function and clinical potential
Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …
RETRACTED ARTICLE: exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7
H Zhang, T Deng, S Ge, Y Liu, M Bai, K Zhu, Q Fan, J Li… - Oncogene, 2019 - nature.com
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …
MSC exosome works through a protein-based mechanism of action
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
Mesenchymal stem/stromal cell-derived extracellular vesicles and their potential as novel immunomodulatory therapeutic agents
V Börger, M Bremer, R Ferrer-Tur, L Gockeln… - International journal of …, 2017 - mdpi.com
Extracellular vesicles (EVs), such as exosomes and microvesicles, have been identified as
mediators of a newly-discovered intercellular communication system. They are essential …
mediators of a newly-discovered intercellular communication system. They are essential …
Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment
Exosomes are extracellular vesicles with the size of 40–100 nm in diameter and a density of
1.13–1.19 g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the …
1.13–1.19 g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the …