Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Mesenchymal stem cell-derived exosomes for clinical use

M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …

Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome

CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

S Zhang, KYW Teo, SJ Chuah, RC Lai, SK Lim… - Biomaterials, 2019 - Elsevier
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …

Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

RETRACTED ARTICLE: exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

H Zhang, T Deng, S Ge, Y Liu, M Bai, K Zhu, Q Fan, J Li… - Oncogene, 2019 - nature.com
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing
incidence and poor prognosis. Adipose tissue is known to function in energy storage and …

MSC exosome works through a protein-based mechanism of action

WS Toh, RC Lai, B Zhang, SK Lim - Biochemical Society …, 2018 - portlandpress.com
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment

WS Toh, RC Lai, JHP Hui, SK Lim - Seminars in cell & developmental …, 2017 - Elsevier
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …

Mesenchymal stem/stromal cell-derived extracellular vesicles and their potential as novel immunomodulatory therapeutic agents

V Börger, M Bremer, R Ferrer-Tur, L Gockeln… - International journal of …, 2017 - mdpi.com
Extracellular vesicles (EVs), such as exosomes and microvesicles, have been identified as
mediators of a newly-discovered intercellular communication system. They are essential …

Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

Y Yaghoubi, AA Movassaghpour, M Zamani, M Talebi… - Life sciences, 2019 - Elsevier
Exosomes are extracellular vesicles with the size of 40–100 nm in diameter and a density of
1.13–1.19 g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the …