Cells are mechanically coupled to their extracellular environments, which play critical roles
in both communicating the state of the mechanical environment to the cell as well as in …

Spherical aberration (SA) occurs when light rays entering at different points of a spherical
lens are not focused to the same point of the optical axis. SA that occurs inside the lens …

The effect of refractive‐index mismatch, as encountered in the observation of biological
specimens, on the image acquisition process in confocal fluorescence microscopy is …

In 1995, we reported the construction of a video-rate scanning laser confocal microscope for
imaging human skin in vivo. Since then, we have improved the resolution, contrast, depth of …

Cell invasion through a dense three-dimensional (3D) matrix is believed to depend on the
ability of cells to generate traction forces. To quantify the role of cell tractions during invasion …

Single-objective selective-plane illumination microscopy (soSPIM) is achieved with
micromirrored cavities combined with a laser beam–steering unit installed on a standard …

Noninvasive techniques that provide detailed information about molecular composition,
structure, and interactions are crucial to further our understanding of the relation between …

Background & Aims: The cause of slow-transit constipation is incompletely understood.
Recent observations suggest a central role for interstitial cells of Cajal in the control of …

Abstract A three-dimensional (3-D) full-field measurement technique was developed for
measuring large deformations in optically transparent soft materials. The technique utilizes a …

Background: Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are
found throughout the human colon and are decreased in the sigmoid colon of patients with …