Aminoacyl–transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct
amino acid to its corresponding tRNA during translation of the genetic code, are proven …

Aminoacyl-tRNA synthetases are essential enzymes that help to ensure the fidelity of protein
translation by accurately aminoacylating (or “charging”) specific tRNA substrates with …

Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule
by functioning as a biological link between the genetic nucleotide sequence in the mRNA …

Background: Error-prone aminoacyl-tRNA synthetases clear noncognate aminoacyl-
adenylates and misacylated tRNAs within synthetic and editing sites, respectively. Results …

Many aminoacyl-tRNA synthetases (aaRSs) contain two active sites, a synthetic site
catalyzing aminoacyl-adenylate formation and tRNA aminoacylation and a second editing or …

The central dogma and its accurate interpretation by a large array of biomolecules remains a
fascinating process. Understanding its mechanisms of decoding holds tremendous potential …

To prevent potential errors in protein synthesis, some aminoacyl-transfer RNA (tRNA)
synthetases have evolved editing mechanisms to hydrolyze misactivated amino acids (pre …

2014-01-15 Assigned to ATYR PHARMA, INC. reassignment ATYR PHARMA, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

TARS and TARS2 encode cytoplasmic and mitochondrial threonyl-tRNA synthetases
(ThrRSs) in mammals, respectively. Interestingly, in higher eukaryotes, a third gene …

To prevent genetic code ambiguity due to misincorporation of amino acids into proteins,
aminoacyl-tRNA synthetases have evolved editing activities to eliminate intermediate or final …