An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site
FL Rock, W Mao, A Yaremchuk, M Tukalo, T Crépin… - science, 2007 - science.org
Aminoacyl–transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct
amino acid to its corresponding tRNA during translation of the genetic code, are proven …
amino acid to its corresponding tRNA during translation of the genetic code, are proven …
In vitro assays for the determination of aminoacyl-tRNA synthetase editing activity
KE Splan, K Musier-Forsyth, MT Boniecki, SA Martinis - Methods, 2008 - Elsevier
Aminoacyl-tRNA synthetases are essential enzymes that help to ensure the fidelity of protein
translation by accurately aminoacylating (or “charging”) specific tRNA substrates with …
translation by accurately aminoacylating (or “charging”) specific tRNA substrates with …
Transfer RNA: a dancer between charging and mis-charging for protein biosynthesis
Z XiaoLong, W EnDuo - Science China Life Sciences, 2013 - Springer
Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule
by functioning as a biological link between the genetic nucleotide sequence in the mRNA …
by functioning as a biological link between the genetic nucleotide sequence in the mRNA …
Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic steps
Background: Error-prone aminoacyl-tRNA synthetases clear noncognate aminoacyl-
adenylates and misacylated tRNAs within synthetic and editing sites, respectively. Results …
adenylates and misacylated tRNAs within synthetic and editing sites, respectively. Results …
An aminoacyl-tRNA synthetase with a defunct editing site
SW Lue, SO Kelley - Biochemistry, 2005 - ACS Publications
Many aminoacyl-tRNA synthetases (aaRSs) contain two active sites, a synthetic site
catalyzing aminoacyl-adenylate formation and tRNA aminoacylation and a second editing or …
catalyzing aminoacyl-adenylate formation and tRNA aminoacylation and a second editing or …
Fidelity mechanisms of the aminoacyl-tRNA synthetases
AP Mascarenhas, S An, AE Rosen, SA Martinis… - Protein …, 2009 - Springer
The central dogma and its accurate interpretation by a large array of biomolecules remains a
fascinating process. Understanding its mechanisms of decoding holds tremendous potential …
fascinating process. Understanding its mechanisms of decoding holds tremendous potential …
Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
To prevent potential errors in protein synthesis, some aminoacyl-transfer RNA (tRNA)
synthetases have evolved editing mechanisms to hydrolyze misactivated amino acids (pre …
synthetases have evolved editing mechanisms to hydrolyze misactivated amino acids (pre …
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
KP Chiang, JD Watkins, AP Vasserot, CL Quinn… - US Patent …, 2015 - Google Patents
2014-01-15 Assigned to ATYR PHARMA, INC. reassignment ATYR PHARMA, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities
TARS and TARS2 encode cytoplasmic and mitochondrial threonyl-tRNA synthetases
(ThrRSs) in mammals, respectively. Interestingly, in higher eukaryotes, a third gene …
(ThrRSs) in mammals, respectively. Interestingly, in higher eukaryotes, a third gene …
tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase
To prevent genetic code ambiguity due to misincorporation of amino acids into proteins,
aminoacyl-tRNA synthetases have evolved editing activities to eliminate intermediate or final …
aminoacyl-tRNA synthetases have evolved editing activities to eliminate intermediate or final …