Immunotherapy with checkpoint inhibitors has greatly prolonged the overall survival of
cancer patients in melanoma and many other cancer types. However, only a subset of …

For decades, lactate has been considered an innocuous bystander metabolite of cellular
metabolism. However, emerging studies show that lactate acts as a complex …

Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …

Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …

Despite the dramatic antitumor efficiency of certain immune checkpoint inhibitors,
immunotherapy has met a bottleneck regarding the response rate and resistance in cancer …

Pancreatic ductal adenocarcinoma (PDA) is associated with activation of WNT signaling.
Whether this signaling pathway regulates the tumor microenvironment has remained …

Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling
plays essential roles in processes across species. The roles of Wnt signaling proteins and …

The Wingless (Wnt)/β-catenin pathway has long been associated with tumorigenesis, tumor
plasticity, and tumor-initiating cells called cancer stem cells (CSCs). Wnt signaling has …

Wnt signaling is one of the important pathways to play a major role in various biological
processes, such as embryonic stem-cell development, tissue regeneration, cell …

The vast majority of cancer-related deaths are due to metastasis, a process that requires
evasion of the host immune system. In addition, a significant percentage of cancer patients …