Flavonoids regulate tumor-associated macrophages–from structure-activity relationship to clinical potential

Q Sun, Q Liu, X Zhou, X Wang, H Li, W Zhang… - Pharmacological …, 2022 - Elsevier
In recent years, the strategy for tumor therapy has changed from focusing on the direct killing
effect of different types of therapeutic agents on cancer cells to the new mainstream of multi …

The multifunctional roles of flavonoids against the formation of advanced glycation end products (AGEs) and AGEs-induced harmful effects

Q Zhou, KW Cheng, J Xiao, M Wang - Trends in Food Science & …, 2020 - Elsevier
Background Advanced glycation end products (AGEs) play a crucial role in the onset,
progression, and propagation of both macroangiopathy and microangiopathy complications …

Hepatoprotective Effect of Apigenin Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro

S Yue, N Xue, H Li, B Huang, Z Chen, X Wang - Inflammation, 2020 - Springer
Apigenin, a flavonoid found in many plants, has various biological properties. We aimed to
investigate the anti-inflammatory and anti-oxidative activity of apigenin against carbon …

[HTML][HTML] Dicarbonyl stress at the crossroads of healthy and unhealthy aging

C Nigro, A Leone, F Fiory, I Prevenzano, A Nicolò… - Cells, 2019 - mdpi.com
Dicarbonyl stress occurs when dicarbonyl metabolites (ie, methylglyoxal, glyoxal and 3-
deoxyglucosone) accumulate as a consequence of their increased production and/or …

Mechanistic studies of inhibition on acrolein by myricetin

D Zhang, X Jiang, L Xiao, Y Lu, S Sang, L Lv, W Dong - Food chemistry, 2020 - Elsevier
Acrolein (ACR) is an unsaturated aldehyde with high activity and toxicity and is produced in
vivo and in food. This study investigated the impact of B-ring structure on the trapping of …

[HTML][HTML] Apigenin attenuates atherosclerosis and non-alcoholic fatty liver disease through inhibition of NLRP3 inflammasome in mice

Z Lu, L Liu, S Zhao, J Zhao, S Li, M Li - Scientific Reports, 2023 - nature.com
Apigenin (APN), a flavone found in several plant foods with various biological properties
such as anti-obesity, anti-inflammation and other abilities, alleviates atherosclerosis and non …

Scavenging Glyoxal and Methylglyoxal by Synephrine Alone or in Combination with Neohesperidin at High Temperatures

Y Liang, R Du, X Zhao, Y Xu, Q Xiang… - Journal of Agricultural …, 2024 - ACS Publications
α-Dicarbonyl compounds, such as glyoxal (GO) and methylglyoxal (MGO), are a series of
chemical hazards that exist in vivo and in vitro, posing a threat to human health. We aimed to …

Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway

A Parveen, R Sultana, SM Lee, TH Kim… - Archives of Pharmacal …, 2021 - Springer
The role of advanced glycation end products (AGEs) is not limited to diabetes and diabetes-
related complications. There are multiple modulators, including the receptor for advanced …

Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway

K Xu, Y Yang, M Lan, J Wang, B Liu, M Yan… - European journal of …, 2023 - Elsevier
Apigenin is a natural flavonoid which is widely found in vegetables and fruits. However, the
mechanism of apigenin in oxidative stress-induced myocardial injury has not been fully …

Translating In Vitro Acrolein‐Trapping Capacities of Tea Polyphenol and Soy Genistein to In Vivo Situation is Mediated by the Bioavailability and Biotransformation of …

Q Huang, Y Zhu, L Lv, S Sang - Molecular nutrition & food …, 2020 - Wiley Online Library
Scope Acrolein (ACR) is a highly toxic unsaturated aldehyde. Humans are both
endogenously and exogenously exposed to ACR. Long‐term exposure to ACR leads to …