The placenta in fetal growth restriction: what is going wrong?
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …
Placental adaptation: what can we learn from birthweight: placental weight ratio?
CE Hayward, S Lean, CP Sibley, RL Jones… - Frontiers in …, 2016 - frontiersin.org
Appropriate fetal growth relies upon adequate placental nutrient transfer. Birthweight:
placental weight ratio (BW: PW ratio) is often used as a proxy for placental efficiency, defined …
placental weight ratio (BW: PW ratio) is often used as a proxy for placental efficiency, defined …
[HTML][HTML] Selective targeting of a novel vasodilator to the uterine vasculature to treat impaired uteroplacental perfusion in pregnancy
N Cureton, I Korotkova, B Baker, S Greenwood… - Theranostics, 2017 - ncbi.nlm.nih.gov
Fetal growth restriction (FGR) in pregnancy is commonly caused by impaired uteroplacental
blood flow. Vasodilators enhance uteroplacental perfusion and fetal growth in humans and …
blood flow. Vasodilators enhance uteroplacental perfusion and fetal growth in humans and …
Flow in fetoplacental-like microvessels in vitro enhances perfusion, barrier function, and matrix stability
M Cherubini, S Erickson, P Padmanaban… - Science …, 2023 - science.org
Proper placental vascularization is vital for pregnancy outcomes, but assessing it with
animal models and human explants has limitations. We introduce a 3D in vitro model of …
animal models and human explants has limitations. We introduce a 3D in vitro model of …
Treating the dysfunctional placenta
CP Sibley - Journal of Endocrinology, 2017 - joe.bioscientifica.com
Placental dysfunction underlies major obstetric diseases such as pre-eclampsia and fetal
growth restriction (FGR). Whilst there has been a little progress in prophylaxis, there are still …
growth restriction (FGR). Whilst there has been a little progress in prophylaxis, there are still …
Piezo1 channels are mechanosensors in human fetoplacental endothelial cells
STUDY QUESTION Does the shear stress sensing ion channel subunit Piezo1 have an
important mechanotransduction role in human fetoplacental endothelium? SUMMARY …
important mechanotransduction role in human fetoplacental endothelium? SUMMARY …
Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease
Experimental methods that allow examination of the intact vascular network of large organs,
such as the human placenta are limited, preventing adequate comparison of normal and …
such as the human placenta are limited, preventing adequate comparison of normal and …
Causal relationship between obesity-related traits and TLR4-driven responses at the maternal–fetal interface
Aims/hypothesis Obesity triggers complex inflammatory networks within the innate immune
system. During pregnancy, the placenta amplifies the low-grade inflammation through …
system. During pregnancy, the placenta amplifies the low-grade inflammation through …
[HTML][HTML] Placental blood flow sensing and regulation in fetal growth restriction
The mechanical force of blood flow is a fundamental determinant of vascular homeostasis.
This frictional stimulation of cells, fluid shear stress (FSS), is increasingly recognised as …
This frictional stimulation of cells, fluid shear stress (FSS), is increasingly recognised as …
Pregnancy‐associated venous insufficiency course with placental and systemic oxidative stress
MA Ortega, B Romero, Á Asúnsolo… - Journal of Cellular …, 2020 - Wiley Online Library
The development of lower extremity venous insufficiency (VI) during pregnancy has been
associated with placental damage. VI is associated with increased oxidative stress in …
associated with placental damage. VI is associated with increased oxidative stress in …