Although the concept of energy starvation in the failing heart was proposed decades ago,
still very little is known about the origin of energetic failure. Recent advances in molecular …

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines
in skeletal muscle mitochondria are thought to play a primary role in this process …

Mitochondrial dysfunction is considered one of the hallmarks of ischemia/reperfusion injury.
Mitochondria are plastic organelles that undergo continuous biogenesis, fusion, and fission …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Skeletal muscle atrophy is the consequence of protein degradation exceeding protein
synthesis. This arises for a multitude of reasons including the unloading of muscle during …

Background and Purpose—Mitochondrial biogenesis is regulated through the coordinated
actions of both nuclear and mitochondrial genomes to ensure that the organelles are …

To investigate a possible new physiological role of carbon monoxide (CO), an endogenous
gas involved in cell signaling and cytotoxicity, we tested the hypothesis that the …

Abstract Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital
cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine …

Retinitis pigmentosa (RP) is an inherited retinal disease affecting> 20 million people
worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone …

Mitochondria play a central role in cell fate after stressors such as ischemic brain injury. The
convergence of intracellular signaling pathways on mitochondria and their release of critical …