Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in elderly
people. Considering the multifactorial nature of AD, the concept of multi-target-directed …

Molecular chameleons possess a flexibility that allows them to dynamically shield or expose
polar functionalities in response to the properties of the environment. Although the concept …

Lead optimization of a series of tryptophan-based nanomolar butyrylcholinesterase (BChE)
inhibitors led to tertiary amines as highly potent, achiral, sp 3-rich analogues with better …

Butyrylcholinesterase (BChE) is recently regarded as a biomarker in progressed Alzheimer's
disease (AD), the development of selective BChE inhibitors has attracted a great deal of …

Alzheimer's disease (AD), a neurodegenerative condition associated with ageing, can occur.
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …

Acetylcholinesterase and butyrylcholinesterase are the two enzymes involved in the
cholinergic system and its modulation. These enzymes have been recognized as …

Highlights•BChE is considered a promising drug target for the treatment of moderate to
severe Alzheimer's disease.•The development of selective BChE inhibitors will move on …

A class of novel δ-sulfonolactone-fused pyrazole scaffold was prepared via sulfur (VI)
fluoride exchange (SuFEx) chemistry using aryl sulfonyl fluorides and pyrazolones. Enzyme …

Alzheimer's disease (AD) is a multifactorial neurodegenerative process whose effective
treatment will require drugs that can act simultaneously on multiple pathogenic targets …