The CYP51 family is an intriguing subject for fundamental P450 structure/function studies
and is also an important clinical drug target. This review updates information on the variety …

Spermiogenesis is a long process whereby haploid spermatids derived from the meiotic
divisions of spermatocytes undergo metamorphosis into spermatozoa. It is subdivided into …

The obligatory step in sterol biosynthesis in eukaryotes is demethylation of sterol precursors
at the C14-position, which is catalyzed by CYP51 (sterol 14-alpha demethylase) in three …

Mammals express multiple cytochromes P450 simultaneously in a variety of tissues,
including the liver, kidney, lung, adrenal, gonads, brain, and most others. For cytochromes …

Mammalian spermatogenesis is a complex developmental program in which a diploid
progenitor germ cell transforms into highly specialized spermatozoa. One intriguing aspect …

Eukaryotic cells can synthesize thousands of different lipid molecules that are incorporated
into their membranes. This involves the activity of hundreds of enzymes with the task of …

This review focuses on the non-statin strategies for the treatment of hyperlipidemias in
humans. Even if statins remain the major hypolipidemic drugs at present, an increasing …

This review describes the mouse knockout models of cholesterol synthesis, together with
human malformations and drugs that target cholesterogenic enzymes. Generally, the sooner …

Many hepatic cytochrome P450 enzymes and their associated drug metabolizing activities
are down-regulated in disease states, and much of this has been associated with …

The Magnaporthe oryzae genome contains two homologous CYP51 genes, MoCYP51A and
MoCYP51B, that putatively encode sterol 14α-demethylase enzymes. Targeted gene …