Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting

A Meyer, J Auernheimer, A Modlinger… - Current …, 2006 - ingentaconnect.com
Integrins constitute an important class of cell adhesion receptors responsible not only for cell-
matrix adhesion but also for signaling bidirectionally across the membrane. Integrins are …

Recent advances in the synthesis of 2H-1, 4-benzoxazin-3-(4H)-ones and 3, 4-dihydro-2H-1, 4-benzoxazines

J Ilaš, PŠ Anderluh, MS Dolenc, D Kikelj - Tetrahedron, 2005 - Elsevier
The 2H-1, 4-benzoxazin-3-(4H)-one (1) and 3, 4-dihydro-2H-1, 4-benzoxazine (2) scaffolds
have been studied intensively as important heterocyclic systems for building natural 1, 2 and …

Green fabrication of ferromagnetic Fe 3 O 4 nanoparticles and their novel catalytic applications for the synthesis of biologically interesting benzoxazinone and …

N Basavegowda, KBS Magar, K Mishra… - New Journal of …, 2014 - pubs.rsc.org
This paper demonstrates a novel and green approach for the synthesis of Fe3O4
nanoparticles using the leaf extract of Artemisia annua (A. annua), which is widely …

New series of 6-substituted coumarin derivatives as effective factor Xa inhibitors: Synthesis, in vivo antithrombotic evaluation and molecular docking

KM Amin, NMA Gawad, DEA Rahman… - Bioorganic chemistry, 2014 - Elsevier
Despite recent progress in antithrombotic therapy, there's still an unmet medical need for
safe and orally available anticoagulants. Encouraged by the marked antithrombotic and …

3,4-Dihydro-2H-1,4-benzoxazine Derivatives Combining Thrombin Inhibitory and Glycoprotein IIb/IIIa Receptor Antagonistic Activity as a Novel Class of …

J Ilaš, Z Jakopin, T Borštnar… - Journal of medicinal …, 2008 - ACS Publications
3, 4-Dihydro-2 H-1, 4-benzoxazine derivatives possessing both thrombin inhibitory and
glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonistic activities were obtained by combining …

[HTML][HTML] Perlite-SO3H nanoparticles as an efficient and reusable catalyst for one-pot three-component synthesis of 1, 2-dihydro-1-aryl-naphtho [1, 2-e][1, 3] oxazine-3 …

A Ramazani, M Rouhani, E Mirhadi… - Nanochemistry …, 2016 - nanochemres.org
A general synthetic route for the synthesis of 1, 2-dihydro-1-aryl-naphtho [1, 2-e][1, 3]
oxazine-3-one derivatives has been developed using perlite-SO3H nanoparticles as …

Small molecule antagonists of integrin receptors

A Perdih, M Sollner Dolenc - Current medicinal chemistry, 2010 - ingentaconnect.com
The complex and widespread family of integrin receptors is involved in numerous
physiological processes, such as tissue remodeling, angiogenesis, development of the …

A simple and facile route for the synthesis of 2H-1, 4-benzoxazin-3-(4H)-ones via reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe …

C Ramesh, BR Raju, V Kavala, CW Kuo, CF Yao - Tetrahedron, 2011 - Elsevier
A simple route for the synthesis of 1, 4-benzoxazin-3-(4H)-ones is described herein. This
method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the …

Conjugation to hyperbranched polyglycerols improves RGD-mediated inhibition of platelet function in vitro

JG Zhang, OB Krajden, RK Kainthan… - Bioconjugate …, 2008 - ACS Publications
RGD (arginine-glycine-aspartic acid) is a known peptide sequence that binds platelet
integrin GPIIbIIIa and disrupts platelet− fibrinogen binding and platelet cross-linking during …

Potential anti-proliferative agents from 1, 4-benzoxazinone-quinazolin-4 (3H)-one templates

R Bollu, S Banu, S Kasaboina, R Bantu… - Bioorganic & Medicinal …, 2017 - Elsevier
A novel synthetic protocol has been developed for the synthesis of 1, 4-benzoxazinone-
acetylphenylallyl quinazolin-4 (3H)-one hybrids 7a–n by employing Pd-catalyzed Csingle …