Background Acute postoperative pain is common. Nearly 20 per cent of patients experience
severe pain in the first 24 h after surgery, a figure that has remained largely unchanged in …

Surgical procedures are key drivers of pain development and opioid utilization globally.
Various organizations have generated guidance on postoperative pain management …

Objectives The primary study objective was to investigate the impact of surveillance
monitoring (ie, continuous monitoring optimized for deterioration detection) on mortality and …

In terms of antinociceptive action, the main mode of action of magnesium involves its
antagonist action at the N-methyl-d-aspartate (NMDA) receptor, which prevents central …

With a focus on practical acute pain management in adults in the hospital setting, this book
provides health professionals with simple and practical information to help them manage …

Purpose Opioids have long been used to treat acute postsurgical and postprocedural pain;
however, opioid-related adverse events (AEs) contribute to poor patient outcomes. In …

Worldwide, 80% of patients who undergo surgery receive opioid analgesics as the
fundamental agent for pain relief. However, the irrational use of opioids leads to excessive …

Background Excessive opioid prescribing after surgery has been recognised as a
contributor to the current crisis of opioid addiction and overdose. Clinicians may potentially …

Postoperative pain is a common but often inadequately treated condition. Enhanced
recovery pathways (ERPs) are increasingly being utilized to standardize perioperative care …

Background Pain management with conventional opioids can be challenging due to dose-
limiting adverse events (AEs), some of which may be related to the simultaneous activation …