Spreading depression, spreading depolarizations, and the cerebral vasculature

C Ayata, M Lauritzen - Physiological reviews, 2015 - journals.physiology.org
Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm

MJ Rowland, G Hadjipavlou, M Kelly… - British journal of …, 2012 - academic.oup.com
Despite improvements in the clinical management of aneurysmal subarachnoid
haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single …

[HTML][HTML] Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during …

JP Dreier, CL Lemale, V Kola, A Friedman… - …, 2018 - Elsevier
Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures
that only occurs under pathological conditions. In the present paper, we summarize the …

Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

H Nakamura, AJ Strong, C Dohmen, OW Sakowitz… - Brain, 2010 - academic.oup.com
How does infarction in victims of stroke and other types of acute brain injury expand to its
definitive size in subsequent days? Spontaneous depolarizations that repeatedly spread …

Neurovascular mechanisms of migraine and cluster headache

J Hoffmann, SM Baca… - Journal of Cerebral Blood …, 2019 - journals.sagepub.com
Vascular theories of migraine and cluster headache have dominated for many years the
pathobiological concept of these disorders. This view is supported by observations that …

Cortical spreading depression as a target for anti-migraine agents

C Costa, A Tozzi, I Rainero, LM Cupini… - The journal of headache …, 2013 - Springer
Spreading depression (SD) is a slowly propagating wave of neuronal and glial
depolarization lasting a few minutes, that can develop within the cerebral cortex or other …

Fiber-based electrochemical biosensors for monitoring pH and transient neurometabolic lactate

MA Booth, SAN Gowers, M Hersey, IC Samper… - Analytical …, 2021 - ACS Publications
Developing tools that are able to monitor transient neurochemical dynamics is important to
decipher brain chemistry and function. Multifunctional polymer-based fibers have been …

Estrogen modulation of cortical spreading depression

C Kudo, AM Harriott, MA Moskowitz, C Waeber… - The journal of headache …, 2023 - Springer
Background and aims Cortical spreading depression (CSD), a transient neuronal and glial
depolarization that propagates slowly across the cerebral cortex, is the putative …

Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice

K Eikermann-Haerter, I Yuzawa, T Qin… - Journal of …, 2011 - Soc Neuroscience
Familial hemiplegic migraine type 1, a monogenic migraine variant with aura, is linked to
gain-of-function mutations in the CACNA1A gene encoding CaV2. 1 channels. The S218L …

Spreading depression as an innate antiseizure mechanism

I Tamim, DY Chung, AL de Morais, ICM Loonen… - Nature …, 2021 - nature.com
Spreading depression (SD) is an intense and prolonged depolarization in the central
nervous systems from insect to man. It is implicated in neurological disorders such as …