Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused
by a complex interplay of genetic and environmental factors. Information on various aspects …

The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous
interest in mental health research owing to its rapid antidepressant actions, but its …

Neurodegenerative diseases are a heterogeneous group of disorders that are characterized
by the progressive dysfunction and loss of neurons. Here, we distil and discuss the current …

Traditional pre-publication peer review of scientific output is a slow, inefficient, and
unreliable process. Efforts to replace or supplement traditional evaluation models with open …

Over the past decades, our view of astrocytes has switched from passive support cells to
active processing elements in the brain. The current view is that astrocytes shape neuronal …

Successful clinical development of new therapeutic interventions is notoriously difficult,
especially in neurodegenerative diseases, where predictive biomarkers are scarce and …

A crucial question that must be addressed in the drug development process is whether the
proposed therapeutic target will yield the desired effect in the clinical population …

Activation of several subtypes of glutamate receptors contributes to changes in postsynaptic
calcium concentration at hippocampal synapses, resulting in various types of changes in …

Mesiotemporal lobe Epilepsy (MTLE), the most frequent form of focal epilepsy, is often drug-
resistant. Enriching the epileptic focus with GABA-releasing engineered cells has been …

One of the fundamental characteristics of the brain is its hierarchical organization. Scales in
both space and time that must be considered when integrating across hierarchies of the …