[HTML][HTML] Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

[HTML][HTML] Sex/gender-related differences in inflammaging

F Olivieri, F Marchegiani, G Matacchione… - Mechanisms of ageing …, 2023 - Elsevier
Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

[HTML][HTML] Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?

N Lott, CE Gebhard, S Bengs, A Haider… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a clear sex
disparity in clinical outcomes. Hence, the interaction between sex hormones, virus entry …

Association of frailty, age, and biological sex with severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine–induced immunity in older adults

JR Shapiro, I Sitaras, HS Park… - Clinical Infectious …, 2022 - academic.oup.com
Background Male sex and old age are risk factors for severe coronavirus disease 2019, but
the intersection of sex and aging on antibody responses to severe acute respiratory …

Considering hormones as sex-and gender-related factors in biomedical research: challenging false dichotomies and embracing complexity

JS Williams, MR Fattori, IR Honeyborne, SA Ritz - Hormones and Behavior, 2023 - Elsevier
The inclusion of sex and gender considerations in biomedicine has been increasing in light
of calls from research and funding agencies, governmental bodies, and advocacy groups to …

[HTML][HTML] Why “sex as a biological variable” conflicts with precision medicine initiatives

M DiMarco, H Zhao, M Boulicault, SS Richardson - Cell Reports Medicine, 2022 - cell.com
Policies that require male-female sex comparisons in all areas of biomedical research
conflict with the goal of improving health outcomes through context-sensitive …

Pandemics, past and present: The role of biological anthropology in interdisciplinary pandemic studies

J Dimka, TP van Doren… - American Journal of …, 2022 - Wiley Online Library
Biological anthropologists are ideally suited for the study of pandemics given their strengths
in human biology, health, culture, and behavior, yet pandemics have historically not been a …

[HTML][HTML] Immunological misfiring and sex differences/similarities in early COVID-19 studies: missed opportunities of making a real IMPACT

A Bhargava, JD Knapp - Cells, 2023 - mdpi.com
COVID-19-associated intensive care unit (ICU) admissions were recognized as critical
health issues that contributed to morbidity and mortality in SARS-CoV-2-infected patients …

Sex-inclusive biomedicine: are new policies increasing rigor and reproducibility?

DL Maney, JW Rich-Edwards - Women's Health Issues, 2023 - whijournal.com
Despite the clear need for sex-and gender-informed medicine (Bartz et al., 2020),
biomedical research has a long history of being conducted primarily on men and male …

[HTML][HTML] Oral SARS-CoV-2 spike protein recombinant yeast candidate prompts specific antibody and gut microbiota reconstruction in mice

L Zhang, L Yao, Y Guo, X Li, L Ma, R Sun… - Frontiers in …, 2022 - frontiersin.org
A recent study showed that patients with coronavirus disease 2019 (COVID-19) have
gastrointestinal symptoms and intestinal flora dysbiosis. Yeast probiotics shape the gut …