Obesity and type 2 diabetes are becoming increasingly prevalent worldwide, and both are
associated with an increased incidence and mortality from many cancers. The metabolic …

As the prevalence of diabetes mellitus is substantially increasing worldwide, associated
diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also …

Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin
effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with …

Purpose Studies of the real‐world comparative effectiveness of drugs conducted using
computerized healthcare databases typically involve an incident new‐user cohort design for …

Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

Research on the specific effects of sex and gender on pharmacokinetics and
pharmacodynamics, as well as safety profile tolerability and drug efficacy, of medications …

Background: An association of insulin use and risk of cancer has been reported but
evidence is conflicting and methodological issues have been identified. Objective: To …

In this paper we address methodological aspects of aetiological importance in the link
between diabetes and mortality in patients with cancer. We identified nine key points on the …

Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly worldwide, is well
established as an important risk factor for various types of cancer. Although many factors …

This document represents the official position of the American Association of Clinical
Endocrinologists and the American College of Endocrinology. Where there were no …