In origin, itch can be cutaneous ('pruritoceptive', eg dermatitis), neuropathic (eg multiple
sclerosis), neurogenic (eg cholestasis), mixed (eg uraemia) or psychogenic. Although itch of …

Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver
disease characterized by a triad of chronic cholestasis, circulating anti-mitochondrial …

Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver
disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is …

Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …

EASL Clinical Practice Guidelines (CPG) on the management of cholestatic liver diseases
define the use of diagnostic, therapeutic and preventive modalities, including non-invasive …

Background/Aims: To assess the efficacy and safety of naltrexone for the short and long term
treatment of pruritus of cholestasis. Methods: Twenty patients with pruritus and cholestasis …

During the past two decades, systemic μ-opioid receptor antagonists (MORA) have been
used in the treatment of various forms of chronic pruritus. In a number of case reports, case …

Pruritus is often the most troublesome symptom in patients with chronic liver disease,
particularly when cholestasis is a prominent feature. The exact pathogenesis is unknown …

BACKGROUND: Pruritus is the most common and distressing skin symptom, and treatment
of itch is a problem for thousands of people. The currently available therapies are not very …

Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary
cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial …