Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs
HA González-Ponce, AR Rincón-Sánchez… - Nutrients, 2018 - mdpi.com
Over-the-counter (OTC) analgesics are among the most widely prescribed and purchased
drugs around the world. Most analgesics, including non-steroidal anti-inflammatory drugs …
drugs around the world. Most analgesics, including non-steroidal anti-inflammatory drugs …
Mechanism-based inhibition of CYP450: an indicator of drug-induced hepatotoxicity
S Feng, X He - Current drug metabolism, 2013 - ingentaconnect.com
Xenobiotics are converted by cytochrome P450 (CYP450) into highly reactive metabolites
(RMs) that covalently bind to the catalytic site of the enzyme itself, subsequently causing …
(RMs) that covalently bind to the catalytic site of the enzyme itself, subsequently causing …
Toxicity of copper oxide (CuO) nanoparticles on human blood lymphocytes
Abstract CuO nanoparticles (CuO-NPs) serve several important functions in human life,
particularly in the fields of medicine, engineering, and technology. These nanoparticles have …
particularly in the fields of medicine, engineering, and technology. These nanoparticles have …
Cinnamon aqueous extract attenuates diclofenac sodium and oxytetracycline mediated hepato-renal toxicity and modulates oxidative stress, cell apoptosis, and …
GE Elshopakey, ST Elazab - Veterinary Sciences, 2021 - mdpi.com
Among commonly consumed anti-inflammatory and antimicrobial drugs are diclofenac
sodium (DFS) and oxytetracycline (OTC), especially in developing countries because they …
sodium (DFS) and oxytetracycline (OTC), especially in developing countries because they …
Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug …
M Syed, C Skonberg, SH Hansen - Toxicology in vitro, 2016 - Elsevier
Diclofenac is a widely prescribed NSAID, which by itself and its reactive metabolites (Phase-
I and Phase-II) may be involved in serious idiosyncratic hepatotoxicity. Mitochondrial injury …
I and Phase-II) may be involved in serious idiosyncratic hepatotoxicity. Mitochondrial injury …
Toxic effects of environmentally realistic concentrations of diclofenac in organisms from two distinct trophic levels, Hediste diversicolor and Solea senegalensis
B Nunes, D Daniel, GG Canelas, J Barros… - … and Physiology Part C …, 2020 - Elsevier
The use of pharmaceutical drugs has systematically increased, resulting in their
environmental presence and exertion of effects on non-target aquatic organisms. Diclofenac …
environmental presence and exertion of effects on non-target aquatic organisms. Diclofenac …
Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine
Amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease.
However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical …
However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical …
Mechanistic approach for toxic effects of bupropion in primary rat hepatocytes
Bupropion is a widely prescribed antidepressant/smoke cessation drug. However,
hepatotoxicity is one of its side effects reported in some recipients. The mechanisms by …
hepatotoxicity is one of its side effects reported in some recipients. The mechanisms by …
The effects of diclofenac on early life stages of common carp (Cyprinus carpio)
S Stepanova, E Praskova, L Chromcova… - Environmental …, 2013 - Elsevier
Diclofenac residues have been found in surface water, and thus could present a potential
risk to aquatic species. The aim of this study was to assess the impact of diclofenac on the …
risk to aquatic species. The aim of this study was to assess the impact of diclofenac on the …
Mechanisms of the statins cytotoxicity in freshly isolated rat hepatocytes
Statins are potent drugs, used as lipid‐lowering agents in cardiovascular diseases.
Hepatotoxicity is one of the serious adverse effects of statins, and the exact mechanism of …
Hepatotoxicity is one of the serious adverse effects of statins, and the exact mechanism of …