The skin, which serves as the first barrier of the human body, is particularly susceptible to
exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are …

TWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF
superfamily that controls a multitude of cellular events including proliferation, migration …

Fibrosis is a common pathological condition associated with abnormal repair after tissue
injury. However, the etiology and molecular mechanisms of fibrosis are still not well …

Cardiorenal syndrome (CRS) is a state of coexisting heart failure and renal insufficiency in
which acute or chronic dysfunction of the heart or kidney lead to acute or chronic dysfunction …

Background Cachexia, a complex multi‐organ syndrome, shortens survival time of patients,
particularly those with cancer. Many studies and clinical trials have been carried out to …

Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also
linked to chronic diseases. Despite its physiological and medical importance, the regulation …

Wound healing is a long‐term complex process, in which epidermal stem cells (EPSCs) in
epidermis of skin have been found to play an essential role in it. We develop a noninvasive …

TNF-related weak inducer of apoptosis (TWEAK) belongs to the TNF superfamily, which
expresses its biological effects in several tissues. Being a small pleiotropic cytokine, TWEAK …

Burns are often accompanied by a dysfunctional immune response, which can lead to
systemic inflammation, shock and excessive scarring. The objective of this study was to …

Background Psoriasis is a chronic inflammatory skin disease with disturbed interplay
between immune cells and keratinocytes. A strong IFN-γ signature is characteristic for …