Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder;
however, no disease-modifying interventions are available for patients with this disease. The …

There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …

Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG
repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq) to …

Among the age-dependent protein aggregation disorders, nine neurodegenerative diseases
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …

Astrocytes have in recent years become the focus of intense experimental interest, yet
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …

Competition among adult brain cells has not been extensively researched. To investigate
whether healthy glia can outcompete diseased human glia in the adult forebrain, we …

Astrocytes are implicated in neurodegenerative disorders and may contribute to striatal
neuron loss or dysfunction in Huntington's disease (HD). Here, we assessed striatal …

Astrocytes play important roles in neurological disorders such as stroke, injury, and
neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse …