The increasing prevalence of hospital and community-acquired infections caused by
multidrug-resistant (MDR) bacterial pathogens is limiting the options for effective antibiotic …

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are generally
thought to have high mortality rates. However, many cases can be treated with the right …

Although progress has been made to reduce global incidence of drug-susceptible
tuberculosis, the emergence of multidrug-resistant (MDR) and extensively drug-resistant …

Current nucleic acid amplification methods to detect Mycobacterium tuberculosis are
complex, labor-intensive, and technically challenging. We developed and performed the first …

Background Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic,
expensive, and has generally poor outcomes. We undertook an individual patient data meta …

Linezolid is used off-label to treat multidrug-resistant tuberculosis (MDR-TB) in absence of
systematic evidence. We performed a systematic review and meta-analysis on efficacy …

Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Multidrug-resistant (MDR) tuberculosis is a growing clinical and public-health concern. To
evaluate existing evidence regarding treatment regimens for MDR tuberculosis, we used a …

Background Treatment outcomes for multidrug-resistant Mycobacterium Tuberculosis
(MDRTB) are generally poor compared to drug sensitive disease. We sought to estimate …

Abstract The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received
significant attention as a drug target, however its vulnerability may be affected by its flexibility …