Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …

The amyloid-β (Aβ) peptide has long been considered to be the driving force behind
Alzheimer's disease (AD). However, clinical trials that have successfully reduced Aβ burden …

Alzheimer's disease is a common and devastating disease characterized by aggregation of
the amyloid-β peptide. However, we know relatively little about the underlying molecular …

Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with the
overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau …

Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

Background Rosacea is linked to abnormalities of cutaneous vasculature and dysregulation
of the inflammatory response. Recent reports on rosacea have shown a significant …

Synucleinophaties are progressive neurodegenerative disorders with no cure to date. An
attractive strategy to tackle this problem is repurposing already tested safe drugs against …

Background While additional research is needed, a number of large epidemiological studies
show an association between circadian disruption and metabolic disorders. Specifically …

Neurodegenerative diseases are still a challenge for effective treatments. The high cost of
approved drugs, severity of side effects, injection site pain, and restrictions on drug delivery …