New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Enzymatic carbon–sulfur bond formation in natural product biosynthesis

KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

JC Frisvad, V Hubka, CN Ezekiel, SB Hong… - Studies in …, 2019 - ingentaconnect.com
Aflatoxins and ochratoxins are among the most important mycotoxins of all and producers of
both types of mycotoxins are present in Aspergillus section Flavi, albeit never in the same …

Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Ustilaginoidea virens: Insights into an Emerging Rice Pathogen

W Sun, J Fan, A Fang, Y Li… - Annual review of …, 2020 - annualreviews.org
False smut of rice, caused by Ustilaginoidea virens, has become one of the most important
diseases in rice-growing regions worldwide. The disease causes a significant yield loss and …

Progress and perspectives on directing group-assisted palladium-catalysed C–H functionalisation of amino acids and peptides

S Shabani, Y Wu, HG Ryan, CA Hutton - Chemical Society Reviews, 2021 - pubs.rsc.org
Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …

Post-translational formation of strained cyclophanes in bacteria

TQN Nguyen, YW Tooh, R Sugiyama, TPD Nguyen… - Nature Chemistry, 2020 - nature.com
Cyclic peptide natural products have served as important drug molecules, with several
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

KJ Hetrick, WA van der Donk - Current opinion in chemical biology, 2017 - Elsevier
Highlights•Genome mining software rapidly identifies RiPP gene clusters from many
families.•Such software has enabled surveys of RiPP abundance and chemical …

Heteroatom–heteroatom bond formation in natural product biosynthesis

AJ Waldman, TL Ng, P Wang, EP Balskus - Chemical reviews, 2017 - ACS Publications
Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

Selected fungal natural products with antimicrobial properties

D Jakubczyk, F Dussart - Molecules, 2020 - mdpi.com
Fungal natural products and their effects have been known to humankind for hundreds of
years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye …