The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

In this review, we discuss the pathophysiologic and management aspects of acute
sarcopenia in relation to SARS-CoV-2 infection. COVID-19 is as a multi-organ infectious …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

The review synthesised evidence examining the association between a. loneliness with
inflammation and b. social isolation with inflammation in adults aged 16 or older from the …

Anemia is quite frequently diagnosed in older individuals and is a key indicator of various
reactive and clonal conditions. Many underlying diseases, like myelodysplastic syndrome …

Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …