T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

The immune system is a dynamic feature of each individual and a footprint of our unique
internal and external exposures. Indeed, the type and level of exposure to physical and …

A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of
pathogens, and TCR repertoire size is believed to decline with age. However, the precise …

High-throughput T cell receptor (TCR) sequencing allows the characterization of an
individual's TCR repertoire and directly queries their immune state. However, it remains a …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that is estimated to
affect 35 million people worldwide and is characterized by lymphocytic infiltration, elevated …

Although structural studies of individual T cell receptors (TCRs) have revealed important
roles for both the α and β chain in directing MHC and antigen recognition, repertoire-level …

Abstract Peptide-MHC (pMHC) multimers, usually used as streptavidin-based tetramers,
have transformed the study of Ag-specific T cells by allowing direct detection, phenotyping …

Sparked by the development of genome sequencing technology, the quantity and quality of
data handled in immunological research have been changing dramatically. Various data …

The T cell repertoire in each individual includes T cell receptors (TCRs) of enormous
sequence diversity through the pairing of diverse TCR α-and β-chains, each generated by …

T cells are an integral component of the adaptive immune response via the recognition of
peptides by the cell surface-expressed T cell receptor (TCR). Rearrangement of the TCR …