Morphine is a potent analgesic agent used to control acute or chronic pain. Chronic
administration of morphine results in analgesic tolerance, hyperalgesia, and other side …

Epilepsy, a neurological disorder characterized by recurrent seizures, and diabetes, a
metabolic disorder characterized by impaired regulation of glucose levels, are two distinct …

Inflammation, and the pain that accompanies it, is a natural response of the body. The
licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory, anti-edematous …

Abstract Background: Traditional Persian medicine has introduced effective remedies in
opioid dependence care. One of the most widely used remedies is an herbal formulation …

Metformin (MET), an antidiabetic drug, has shown antioxidative and neuroprotective effects.
In the present investigation, we aimed to study the probable effects of MET on cerebral …

The aim of this study was to evaluate the anti-diabetic drug metformin (Met) effects on the
anxiety and cognitive impairment in ovariectomized mice. Thirty-two female adult mice were …

This study investigated the potential therapeutic effects of the FDA‐approved drug metformin
on cue‐induced reinstatement of cocaine seeking. Metformin (dimethyl‐biguanide) is a first …

ABSTRACT BACKGROUND AND OBJECTIVES: The constant search for bioactive
compounds with anti-inflammatory and antinociceptive activities are of interest to research …

This paper is the forty-first consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Notwithstanding the experimental evidence indicating Withania somnifera Dunal roots
extract (WSE) ability to prolong morphine-elicited analgesia, the mechanisms underlying this …