During cell migration, the movement of the nucleus must be coordinated with the
cytoskeletal dynamics at the leading edge and trailing end, and, as a result, undergoes …

Because of the association between aberrant nuclear structure and tumour grade, nuclear
morphology is an indispensible criterion in the current pathological assessment of cancer …

Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause
misshapen nuclei and altered chromatin organization associated with cancer and …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …

Neoplastic cells are often characterized by specific morphological abnormalities of the
nuclear envelope (NE), which have been used for cancer diagnosis for more than a century …

Laminopathies comprise a group of inherited diseases with variable clinical phenotypes,
caused by mutations in the lamin A/C gene (LMNA). A prominent feature in several of these …

• The lamin molecule‐Domain organization of lamins‐Lamins are divided to type A and type
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …

The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …

Despite decades of research, cancer metastasis remains an incompletely understood
process that is as complex as it is devastating. In recent years, there has been an increasing …