Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

Colorectal cancer (CRC) is often diagnosed at an advanced stage when tumor cell
dissemination has taken place. Chemo-and targeted therapies provide only a limited …

Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal
adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …

Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Cells require tight regulation of the intracellular redox balance and consequently of reactive
oxygen species for proper redox signaling and maintenance of metal (eg, of iron and …

Cisplatin, carboplatin, and oxaliplatin anticancer drugs are commonly used to treat lung,
colorectal, ovarian, breast, head and neck, and genitourinary cancers. However, the efficacy …