The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Synthesis of BODIPY dyes through postfunctionalization of the boron dipyrromethene core

N Boens, B Verbelen, MJ Ortiz, L Jiao… - Coordination Chemistry …, 2019 - Elsevier
Fluorophores based on the 4-bora-3a, 4a-diaza-s-indacene (aka boron dipyrromethene,
boron dipyrrin, or BODIPY) platform have found diverse applications in different fields of …

Scaffold hopping by net photochemical carbon deletion of azaarenes

J Woo, AH Christian, SA Burgess, Y Jiang, UF Mansoor… - Science, 2022 - science.org
Discovery chemists routinely identify purpose-tailored molecules through an iterative
structural optimization approach, but the preparation of each successive candidate in a …

Installing the “magic methyl”–C–H methylation in synthesis

D Aynetdinova, MC Callens, HB Hicks… - Chemical Society …, 2021 - pubs.rsc.org
The selective and efficient C–H methylation of sp2 and sp3 carbon centres has become a
powerful transformation in the synthetic toolbox. Due to the potential for profound changes to …

Alcohols as alkylating agents in heteroarene C–H functionalization

J Jin, DWC MacMillan - Nature, 2015 - nature.com
Redox processes and radical intermediates are found in many biochemical processes,
including deoxyribonucleotide synthesis and oxidative DNA damage. One of the core …

[图书][B] Heterocyclic chemistry

JA Joule - 2020 - taylorfrancis.com
Covering the fundamentals of heterocyclic reactivity and synthesis, this book teaches the
subject in a way that is understandable to graduate students. Recognizing the level at which …

Metal-free C–H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation

JK Matsui, DN Primer, GA Molander - Chemical Science, 2017 - pubs.rsc.org
A photoredox-catalyzed C–H functionalization of heteroarenes using a variety of primary,
secondary, and tertiary alkyltrifluoroborates is reported. Using Fukuzumi's …

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

MAJ Duncton - MedChemComm, 2011 - pubs.rsc.org
The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici
reaction. Such reactions constitute a broad-set of selective CH-functionalization processes …

Iron-catalyzed reactions in organic synthesis

C Bolm, J Legros, J Le Paih, L Zani - Chemical reviews, 2004 - ACS Publications
Metal complexes are essential instruments in the toolbox of organic chemists. The current
requirements for clean, fast, efficient, and selective processes have increased the demand …

Late-stage C–H alkylation of heterocycles and 1, 4-quinones via oxidative homolysis of 1, 4-dihydropyridines

Á Gutiérrez-Bonet, C Remeur, JK Matsui… - Journal of the …, 2017 - ACS Publications
Under oxidative conditions, 1, 4-dihydropyridines (DHPs) undergo a homolytic cleavage,
forming exclusively a Csp3-centered radical that can engage in the C–H alkylation of …