Since the identification of sickle cell trait as a heritable form of resistance to malaria,
candidate gene studies, linkage analysis paired with sequencing, and genome-wide …

Many pathogens continuously change their protein structure in response to immune-driven
selection, resulting in weakened protection even in previously exposed individuals. In …

Human influenza virus evolves to escape neutralization by polyclonal antibodies. However,
we have a limited understanding of how the antigenic effects of viral mutations vary across …

We present a review and primer of methods to understand epidemiological dynamics and
identify past exposures from serological data, referred to as serodynamics. We discuss …

In order to target threatening pathogens, the adaptive immune system performs a continuous
reorganization of its lymphocyte repertoire. Following an immune challenge, the B cell …

Influenza exposures early in life are believed to shape future susceptibility to influenza
infections by imprinting immunological biases that affect cross-reactivity to future influenza …

Current attempts in vaccine delivery systems concentrate on replicating the natural
dissemination of live pathogens, but neglect that pathogens evolve to evade the immune …

Classic ecological theory explains species coexistence in variable environments. While
spatial variation is often treated as an intrinsic feature of a landscape, it may be shaped and …

Respiratory viruses are a common cause of morbidity and mortality around the world.
Viruses like influenza, RSV, and most recently SARS‐CoV‐2 can rapidly spread through a …

An individual's antibody titers to influenza A strains are a result of the complicated interplay
between infection history, cross-reactivity, immune waning, and other factors. It has been …