Introduction: Paclitaxel is a microtubule stabilizer that is currently one of the most utilized
chemotherapeutic agents. Its efficacy in breast, uterine, lung and other neoplasms made its …

Chemotherapy‐induced peripheral neuropathy (CIPN) is a common dose‐limiting toxicity
that affects 30%–40% of patients undergoing cancer treatment. Although multiple …

Over the past decade, there have been significant developments in treatment for ovarian
cancer, yet the lack of targeted therapy with few side effects still represents a major issue …

The field of pharmacogenomics has made great strides in oncology over the last 20 years
and indeed a significant number of pre‐emptive genetic tests are now routinely undertaken …

Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important
paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have …

Chemotherapy-induced peripheral neuropathy (CIPN) can adversely affect completion of
systemic anti-cancer treatment and cause long-term morbidity. Increasingly …

Abstract Cytochrome P450, family 3, subfamily A (CYP3A) enzymes metabolize
approximately 50% of commercially available drugs. Recently, we developed fully …

GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian
cancer treated with paclitaxel plus carboplatin combination chemotherapy: a …

Abstract Ethnopharmacological relevance Marsdenia tenacissima (Roxb.) Wight et Arn is a
vine distributed in southwest area of China and used in folk medicine for treatment of tumors …

Despite the investment in platinum drugs research, cisplatin, carboplatin and oxaliplatin are
still the only Pt-based compounds used as first line treatments for several cancers, with a few …