Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y Xia, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms

P Huang, LY Zhang, YY Tan, SD Chen - Translational Neurodegeneration, 2023 - Springer
The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

F Chen, Y Chen, Q Ke, Y Wang, Z Gong… - Journal of Translational …, 2023 - Springer
Background Recent numerous epidemiology and clinical association studies reported that
ApoE polymorphism might be associated with the risk and severity of coronavirus disease …

Apolipoprotein E and viral infection: Risks and Mechanisms

F Chen, Q Ke, W Wei, L Cui, Y Wang - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Apolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and
cholesterol homeostasis. In addition to being a well-known genetic determinant of both …

Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer's …

J Chen, J Chen, Z Lei, F Zhang, LH Zeng, X Wu… - Translational …, 2023 - nature.com
Although there are indications of a trend towards less severe acute respiratory symptoms
and a decline in overall lethality from the novel Coronavirus Disease 2019 (COVID-19) …

COVID-19 and Alzheimer's Disease Share Common Neurological and Ophthalmological Manifestations: A Bidirectional Risk in the Post-Pandemic Future

G Amadoro, V Latina, E Stigliano, A Micera - Cells, 2023 - mdpi.com
A growing body of evidence indicates that a neuropathological cross-talk takes place
between the coronavirus disease 2019 (COVID-19)-the pandemic severe pneumonia that …

Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders

N Liang, BA Harsch, S Zhou, A Borkowska… - Progress in Lipid …, 2024 - Elsevier
Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous
system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein …

Targeted screening of genetic associations with COVID-19 susceptibility and severity

P Li, Y Ke, W Shen, S Shi, Y Wang, K Lin, X Guo… - Frontiers in …, 2022 - frontiersin.org
The COVID-19 pandemic has resulted in great morbidity and mortality worldwide and
human genetic factors have been implicated in the susceptibility and severity of COVID-19 …

COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability

Y Zhao, X Han, C Li, Y Liu, J Cheng… - Frontiers in …, 2023 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans
can lead to various degrees of tissue and organ damage, of which cardiovascular system …

Human genetic basis of severe or critical illness in COVID-19

XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …