Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Identification of 1, 3, 4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
D Xiao, L Lu, B Liang, Z Xiong, X Xu… - European Journal of …, 2023 - Elsevier
In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
Triazolothiadiazoles and triazolothiadiazines as potent α-glucosidase inhibitors: Mechanistic insights from kinetics studies, molecular docking and dynamics …
Diabetes mellitus has been considered as a serious health problem worldwide due its high
prevalence rate and associated complications. In this context, the current research work …
prevalence rate and associated complications. In this context, the current research work …
Design, synthesis, and in silico studies of quinoline-based-benzo [d] imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
M Noori, A Davoodi, A Iraji, N Dastyafteh, M Khalili… - Scientific Reports, 2022 - nature.com
In this study, 18 novel quinoline-based-benzo [d] imidazole derivatives were synthesized
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
and screened for their α-glucosidase inhibitory potential. All compounds in the series except …
[HTML][HTML] In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing
Diabetes mellitus is a rapidly spreading global metabolic disorder that has serious social,
health, and economic consequences. Herein, we have evaluated in vivo antidiabetic and …
health, and economic consequences. Herein, we have evaluated in vivo antidiabetic and …
Polyhydroquinoline Derivatives for Diabetic Management: Synthesis, in Vitro and in Silico Approaches
F Talab, Zainab, A Alam, M Ali… - Future Medicinal …, 2023 - Taylor & Francis
Background: Medication used to treat Type 2 diabetes by decreasing the absorption of
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
Identification of isobenzofuranone derivatives as promising antidiabetic agents: Synthesis, in vitro and in vivo inhibition of α-glucosidase and α-amylase …
Diabetes mellitus, one of the major health challenges of the 21st century, is associated with
numerous biomedical complications including retinopathy, neuropathy, nephropathy …
numerous biomedical complications including retinopathy, neuropathy, nephropathy …
Synthesis and molecular modeling studies of naphthazarin derivatives as novel selective inhibitors of α-glucosidase and α-amylase
Diabetes mellitus is known as one of the most life-threatening diseases and has attracted
the attention of medicinal chemists. The design and synthesis of novel potential candidates …
the attention of medicinal chemists. The design and synthesis of novel potential candidates …
Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies
The current studies mainly demonstrate the coumarin based azomethine-clubbed thiazoles
synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the …
synthesis and their in-vitro evaluation for the first time against α-glucosidase. Due to the …
Enzymes inhibition and antioxidant potential of medicinal plants growing in Oman
The recent study was designed to explore Dodonaea viscosa, Juniperus excelsa,
Helianthemum lippii, and Euryops pinifolius using methanolic (MeOH) extract. Their …
Helianthemum lippii, and Euryops pinifolius using methanolic (MeOH) extract. Their …