Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …

Increasing environmental distress is associated with a growing asthma incidence; no
treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes …

The developing and mature central nervous system contains neural precursor cells
expressing the proteoglycan NG2. Some of these cells continuously differentiate to myelin …

Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating
food intake, but druggable biochemical pathways that control this response remain elusive …

Replacement of the lost myelin sheath is a therapeutic goal for treating demyelinating
diseases of the central nervous system (CNS), such as multiple sclerosis (MS). The G …

NG2‐expressing cells comprise a population of cycling precursors that can exit the cell cycle
and differentiate into mature oligodendrocytes. As a whole, they display heterogeneous …

The discovery of a potential ligand-targeting G protein-coupled receptor 17 (GPR17) is
important for developing chemotherapeutic agents against glioblastoma multiforme (GBM) …

Oligodendrocytes are the myelin-forming cells in the CNS. They enwrap axons, thus
permitting fast impulse transmission and exerting trophic actions on neurons. Demyelination …

Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in
asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of motor neurons (MN). Importantly, MN degeneration is intimately linked to …