Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Being different multifactorial forms of psychopathology, aggression, depression and suicidal
behavior, which is considered to be violent aggression directed against the self, have …

Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

DNA methylation is a broadly-investigated epigenetic modification that has been considered
as a heritable and reversible change. Previous findings have indicated that DNA methylation …

Depression and anxiety are major global health burdens. Although SSRIs targeting the
serotonergic system are prescribed over 200 million times annually, they have variable …

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders
worldwide and a major public health concern that is associated with grave consequences …

Early-life adversity caused by poor social bonding and deprived maternal care is known to
affect mental wellbeing and physical health. It is a form of chronic social stress that persists …

Esketamine provides an immediate and noticeable antidepressant effect, although the
underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been …

For over three-quarters of a century, organophosphorus (OP) insecticides have been
ubiquitously used in agricultural, residential, and commercial settings and in public health …