The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and
current treatments are less than satisfactory. So, the discovery of novel approaches to treat …

Fragile X Syndrome is the most common form of inherited mental retardation worldwide. A
Fragile X mouse model, fmr1tm1Cgr, with a disruption in the X-linked Fmr1 gene, has three …

2-Methyl-6-(phenylethynyl) pyridine (3), a potent noncompetitive mGlu5 receptor antagonist
widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of …

Memory is supported by a specific collection of neurons distributed in broad brain areas, an
engram. Despite recent advances in identifying an engram, how the engram is created …

Anxiety, stress, and trauma-related disorders are a major public health concern in the United
States. Drugs that target the γ-aminobutyric acid or serotonergic system, such as …

Posttraumatic stress disorder (PTSD) is a prevalent and highly disabling disorder, but there
is currently no targeted pharmacological treatment for it. Dysfunction of the glutamate system …

Serotonin reuptake inhibitors and benzodiazepines are evidence-based pharmacological
treatments for Anxiety Disorders targeting serotonin and GABAergic systems, respectively …

Anxiety and stress-related disorders, namely posttraumatic stress disorder (PTSD),
generalized anxiety disorder (GAD), obsessive–compulsive disorder (ODC), social and …