Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …

To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

The Hippo pathway has emerged as a conserved signaling pathway that is essential for the
proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms …

Mechanical forces have been proposed to modulate organ growth, but a molecular
mechanism that links them to growth regulation in vivo has been lacking. We report that …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

Spatial and functional organization of cells in tissues is determined by cell-cell adhesion,
thought to be initiated through trans-interactions between extracellular domains of the …

The three human homologues of Aurora kinases (A, B and C) are essential for proper
execution of various mitotic events and are important for maintaining genomic integrity …

The network of actin filaments is one of the crucial cytoskeletal structures contributing to the
morphological framework of a cell and which participates in the dynamic regulation of …

Cell adhesion systems are defined by their ability to resist detachment force. Our
understanding of the biology of cell–cell adhesions has recently been transformed by the …