Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication
of dialysis, and also causes rare conditions. The many forms of the disorder have one …

The understanding of why and how proteins misfold and aggregate into amyloid fibrils has
increased considerably during recent years. Central to amyloid formation is an increase in …

Amyloid fibril formation is assumed to be the molecular basis for a variety of diseases of
unrelated origin. Despite its fundamental clinical importance, the mechanism of amyloid …

Light-chain (AL) amyloidosis is the most common form of systemic amyloidosis and is
associated with an underlying plasma cell dyscrasia. The disease often is difficult to …

Cardiac involvement in patients with amyloidosis is common. It produces significant clinical
symptoms in about 40% of patients with AL amyloidosis. A significant proportion of patients …

Knowledge about the systemic amyloidoses has increased considerably during the last few
years. This group of diseases is characterized by great biochemical variability, including at …

Light chain (AL) amyloidosis is caused by a usually small plasma-cell clone that is able to
produce the amyloidogenic light chains. They are able to misfold and aggregate, deposit in …

Over 80 different disease‐causing mutations in transthyretin (TTR) have been reported. The
vast majority are inherited in an autosomal dominant manner and are related to amyloid …

Aim The spectrum of histological alterations, namely atrial amyloidosis, in the right and left
atria of patients with chronic persistent atrial fibrillation (AF) and rheumatic heart disease is …

ABSTRACT Transthyretin Leu55Pro is one of the most aggressive mutations in familial
amyloidotic polyneuropathy, an autosomal dominant disorder characterized by extracellular …